PDRN has been studied for decades in dermatology. In the early 2000s, researchers in Italy and Korea explored its use in medical treatments focused on supporting skin recovery after procedures. Today, its cosmetic-grade form is adapted for topical skincare to enhance the skin’s overall appearance.

PDRN interacts with A2A receptors in the skin, supporting natural processes that help maintain a smooth and radiant appearance. Research, including a 2016 study published in the International Journal of Molecular Sciences, has explored PDRN’s role in skin health and renewal, highlighting its potential as part of advanced cosmetic science.

MC-PDRN is a cosmetic-grade version created by Morechem Co., Ltd. in South Korea. It’s made from purified salmon DNA, then broken down into smaller, skin-absorbable molecules. This form is highly stable, safe for daily use, and designed to deliver clinical-level results without irritation.

MC-PDRN increases the growth of fibroblasts, the skin cells responsible for producing collagen and elastin. In lab tests, a 10% concentration of MC-PDRN increased cell activity by up to 37%, helping skin feel firmer and more youthful.

Exposure to UV rays increases an enzyme called MMP-1, which breaks down collagen. MC-PDRN was shown to reduce MMP-1 levels by 23%, helping to preserve skin elasticity and prevent sagging.

Collagen is key to skin’s structure and bounce. MC-PDRN is known for supporting the conditions that help maintain collagen integrity and elasticity. In laboratory studies on ingredient activity (not product performance), PDRN showed an increase in collagen-related markers by up to 25% at a 10% concentration.

PDRN has been researched for over two decades in dermatology. A 2013 study published in Dermatology Research and Practice evaluated its role in professional skin care settings, reinforcing its well-documented safety profile. Today, cosmetic-grade PDRN is formulated for advanced skincare to help support a smooth, resilient, and healthy-looking complexion.

PDRN doesn’t just hydrate your skin—it teaches your skin to repair itself. It’s a smart, science-backed way to restore elasticity, reduce wrinkles, and improve skin texture over time.

MC-PDRN remains stable under normal storage conditions (even at 45°C), with no change in color or texture. To maintain its potency, it should be stored in a cool, shaded place away from direct sunlight or UV exposure.